This data package contains water chemistry measurements taken 2 to 4 times per year at 6 stations on the north shore of Moorea, French Polynesia: Forereef, Lagoon, Fringing Reef, Cooks Bay, Cooks Bay Stream Mouth, and Offshore (5 km due north). Measurements include standard CTD parameters, nutrients, chlorophyll, phaeopigments, particulate organic carbon and nitrogen, dissolved organic carbon, dissolved inorganic carbon, total alkalinity, water column primary production, and abundance of bacteria. Sampling began in August, 2005. All water samples were collected with Niskin Bottles. CTD data were collected with a SBE19-Plus Seacat Profiler outfitted with WetLabs FLNTURT-221 Flurometer/turbidity sensors. CTD and bottle samples were taken on separate casts at each station. Two additional stations on the Moorea east shore were sampled in August 2005 only: LTER 3 Forereef Water Column, LTER 3 Backreef Water Column. This material is based upon work supported by the U.S. National Science Foundation under Grant No. OCE 16-37396 (and earlier awards) as well as a generous gift from the Gordon and Betty Moore Foundation. Research was completed under permits issued by the French Polynesian Government (Délégation à la Recherche) and the Haut-commissariat de la République en Polynésie Francaise (DTRT) (Protocole d'Accueil 2005-2018). This work represents a contribution of the Moorea Coral Reef (MCR) LTER Site.