In this study, we tested the effects of colony size and seawater turbulence on the response of the common Indo-Pacific branching coral, Pocillopora verrucosa, to different seawater temperatures. Using whole-colony calcification as a response variable, 12 tanks (each 150 l) were used in two trials lasting 14 days to contrast the effects of seawater turbulence (two levels) and temperature (25.5°C vs 29.5°C) on colonies varying in size from ~4 to 13-cm diameter. Turbulence in the tanks was measured as the root mean square (rms) turbulent flow speed (q rms ), which quantified the variation in speed of complex and non-linear flow, regardless of direction. Treatments contrasted low (q rms = 0.63 cm s -1 ) and high (q rms = 2.07 cm s -1 ) turbulence that were ecologically relevant for shallow coral reefs. This worksheet contains data for the table and figures from the manuscript Edmunds and Burgess entitled 'Colony size modulates the calcification response of the coral Pocillopora verrucosa to turbulent flow speed and temperature', Marine Bio, 2017.